• Causes Starting at about age 40, men's testosterone levels drop by about 10% every decade.1 At the same time, another factor in the body called Sex Binding Hormone Globulin, or SHBG, gradually increases. SHBG traps much of the testosterone that is still circulating and makes it unavailable to the body's tissues. What's left over tries to carry on the beneficial work of testosterone and is known as 'bio-available' testosterone.
• Andropause is associated with low 'bio-available' testosterone levels. Every man experiences a decline of bio-available testosterone, but some men's levels dip lower than others. And when this happens these men can experience symptoms of Andropause.
• These symptoms can impact their quality of life and may expose them to other, longer-term risks of low testosterone. It is estimated that 30% of men in their 50s will have testosterone levels low enough to be causing symptoms or to put them at risk.

• 1 Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J of Clin Endocrinol Metab 1991;3:1016-25.
• 2 Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, Perry HMIII. Validation of a Screening Questionnaire for Androgen Deficiency in Aging Males. Metabolism 2000; 48:1239-42.

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